7oat: Difference between revisions

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'''Unreleased structure'''


The entry 7oat is ON HOLD
==Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D==
 
<StructureSection load='7oat' size='340' side='right'caption='[[7oat]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Petrovic, S., Heinemann, U., Roske, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7oat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OAT FirstGlance]. <br>
Description: Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.995&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
[[Category: Heinemann, U]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oat OCA], [https://pdbe.org/7oat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oat RCSB], [https://www.ebi.ac.uk/pdbsum/7oat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oat ProSAT]</span></td></tr>
[[Category: Petrovic, S]]
</table>
[[Category: Roske, Y]]
== Disease ==
[https://www.uniprot.org/uniprot/ASPC1_HUMAN ASPC1_HUMAN] Translocation renal cell carcinoma;Alveolar soft-tissue sarcoma. A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.<ref>PMID:11244503</ref>  A chromosomal aberration involving ASPSCR1 has been found in two patients with of papillary renal cell carcinoma. Translocation t(X;17)(p11.2;q25).<ref>PMID:11358836</ref>
== Function ==
[https://www.uniprot.org/uniprot/ASPC1_HUMAN ASPC1_HUMAN] Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.<ref>PMID:23349634</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heinemann U]]
[[Category: Petrovic S]]
[[Category: Roske Y]]
Retrieved from "https://proteopedia.org/7oat"