1ecr: Difference between revisions

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[[Image:1ecr.gif|left|200px]]


<!--
==ESCHERICHIA COLI REPLICATION TERMINATOR PROTEIN (TUS) COMPLEXED WITH DNA==
The line below this paragraph, containing "STRUCTURE_1ecr", creates the "Structure Box" on the page.
<StructureSection load='1ecr' size='340' side='right'caption='[[1ecr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ecr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ECR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ecr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ecr OCA], [https://pdbe.org/1ecr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ecr RCSB], [https://www.ebi.ac.uk/pdbsum/1ecr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ecr ProSAT]</span></td></tr>
{{STRUCTURE_1ecr| PDB=1ecr |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/TUS_ECOLI TUS_ECOLI] Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/1ecr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ecr ConSurf].
<div style="clear:both"></div>


'''ESCHERICHIA COLI REPLICATION TERMINATOR PROTEIN (TUS) COMPLEXED WITH DNA'''
==See Also==
 
*[[Replication Termination Protein|Replication Termination Protein]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of the Escherichia coli replication-terminator protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7 A resolution. The Tus protein folds into a previously undescribed architecture divided into two domains by a central basic cleft. This cleft accommodates locally deformed B-form Ter DNA and makes extensive contacts with the major groove, mainly through two interdomain beta-strands. The unusual structural features of this complex may explain how the replication fork is halted in only one direction.
[[Category: Escherichia coli B]]
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Kamada K]]
1ECR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECR OCA].
[[Category: Morikawa K]]
 
==Reference==
Structure of a replication-terminator protein complexed with DNA., Kamada K, Horiuchi T, Ohsumi K, Shimamoto N, Morikawa K, Nature. 1996 Oct 17;383(6601):598-603. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8857533 8857533]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Kamada, K.]]
[[Category: Morikawa, K.]]
[[Category: Dna replication]]
[[Category: Dna-binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:56:29 2008''
Retrieved from "https://proteopedia.org/1ecr"