1mpz: Difference between revisions
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==NMR solution structure of native Viperidae lebetina obtusa protein== | ==NMR solution structure of native Viperidae lebetina obtusa protein== | ||
<StructureSection load='1mpz' size='340' side='right'caption='[[1mpz | <StructureSection load='1mpz' size='340' side='right'caption='[[1mpz]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetina_obtusa Macrovipera lebetina obtusa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPZ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [https://pdbe.org/1mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [https://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpz OCA], [https://pdbe.org/1mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpz RCSB], [https://www.ebi.ac.uk/pdbsum/1mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpz ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DIS_MACLO DIS_MACLO] Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin.<ref>PMID:12538900</ref> <ref>PMID:12727812</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Macrovipera lebetina obtusa]] | [[Category: Macrovipera lebetina obtusa]] | ||
[[Category: Calvete | [[Category: Calvete JJ]] | ||
[[Category: Celda | [[Category: Celda B]] | ||
[[Category: Marcinkiewicz | [[Category: Marcinkiewicz C]] | ||
[[Category: Monleon | [[Category: Monleon D]] | ||
[[Category: Moreno-Murciano | [[Category: Moreno-Murciano MP]] | ||
