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==Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C==
==Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C==
<StructureSection load='6yyg' size='340' side='right'caption='[[6yyg]]' scene=''>
<StructureSection load='6yyg' size='340' side='right'caption='[[6yyg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YYG FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YYG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yyg OCA], [https://pdbe.org/6yyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yyg RCSB], [https://www.ebi.ac.uk/pdbsum/6yyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yyg ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Q1B:5-(trifluoromethyloxy)-1,3-dihydroindol-2-one'>Q1B</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yyg OCA], [https://pdbe.org/6yyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yyg RCSB], [https://www.ebi.ac.uk/pdbsum/6yyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yyg ProSAT]</span></td></tr>
</table>
</table>
==See Also==
*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 13:21, 6 November 2024

Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C

6yyg, resolution 1.95Å

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