7nxk: Difference between revisions

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====

==Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[7nxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXK OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7NXK FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7nxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxk OCA], [https://pdbe.org/7nxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxk RCSB], [https://www.ebi.ac.uk/pdbsum/7nxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxk ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=UUB:(~{E})-~{N}-[4-[(1~{R},3~{R})-3-[[5-chloranyl-4-(1~{H}-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide'>UUB</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7nxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxk OCA], [https://pdbe.org/7nxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxk RCSB], [https://www.ebi.ac.uk/pdbsum/7nxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxk ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

== Function ==

[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>

==See Also==

*[[Cyclin 3D structures|Cyclin 3D structures]]

*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Z-disk~~]]

[[Category: Anand K]]

[[Category: Dust S]]

[[Category: Geyer M]]

[[Category: Kaltheuner IH]]

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@@ Line 1: / Line 1: @@
-====
+==Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175==
-<StructureSection load='7nxk' size='340' side='right'caption='[[7nxk]]' scene=''>
+<StructureSection load='7nxk' size='340' side='right'caption='[[7nxk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7nxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXK FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxk OCA], [https://pdbe.org/7nxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxk RCSB], [https://www.ebi.ac.uk/pdbsum/7nxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxk ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=UUB:(~{E})-~{N}-[4-[(1~{R},3~{R})-3-[[5-chloranyl-4-(1~{H}-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide'>UUB</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxk OCA], [https://pdbe.org/7nxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxk RCSB], [https://www.ebi.ac.uk/pdbsum/7nxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxk ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
+== Function ==
+[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>
+==See Also==
+*[[Cyclin 3D structures|Cyclin 3D structures]]
+*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Anand K]]
+[[Category: Dust S]]
+[[Category: Geyer M]]
+[[Category: Kaltheuner IH]]