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==NMR structure of Double-stranded RNA-specific editase Adar==
==NMR structure of Double-stranded RNA-specific editase Adar==
<StructureSection load='2ljh' size='340' side='right'caption='[[2ljh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ljh' size='340' side='right'caption='[[2ljh]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME]] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>
[https://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allain, F H.T]]
[[Category: Allain FH-T]]
[[Category: Barraud, P]]
[[Category: Barraud P]]
[[Category: Dsrbd]]
[[Category: Dsrbm]]
[[Category: Editing]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/2ljh"