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New page: left|200px<br /> <applet load="1axn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1axn, resolution 1.78Å" /> '''THE HIGH RESOLUTION...
 
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[[Image:1axn.gif|left|200px]]<br />
<applet load="1axn" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1axn, resolution 1.78&Aring;" />
'''THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V'''<br />


==Overview==
==THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V==
The structure of recombinant human annexin III was solved to 1.8 A, resolution. Though homologous to annexin I and V, the annexin III, structure shows significant differences. The tryptophan in the calcium, loop of the third domain is exposed to the solvent, as in the structure of, annexin V crystallized in high calcium concentrations, although the, annexin III crystals were prepared at low calcium concentrations. The, position of domain III relative to the other domains is different from, both annexin V and I, suggesting further flexibility of the molecule. The, entire N-terminus of the protein is well-defined in the present structure., The side chain of tryptophan 5 interacts with the hinge region of the, hydrophillic channel, which could have an effect on the potential mobility, of this region, as well as on its possible calcium channel behavior.
<StructureSection load='1axn' size='340' side='right'caption='[[1axn]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1axn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AXN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1axn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1axn OCA], [https://pdbe.org/1axn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1axn RCSB], [https://www.ebi.ac.uk/pdbsum/1axn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1axn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANXA3_HUMAN ANXA3_HUMAN] Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/1axn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1axn ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1AXN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AXN OCA].
*[[Annexin 3D structures|Annexin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The high-resolution crystal structure of human annexin III shows subtle differences with annexin V., Favier-Perron B, Lewit-Bentley A, Russo-Marie F, Biochemistry. 1996 Feb 13;35(6):1740-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8639653 8639653]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Favier-Perron, B.]]
[[Category: Favier-Perron B]]
[[Category: Lewit-Bentley, A.]]
[[Category: Lewit-Bentley A]]
[[Category: Russo-Marie, F.]]
[[Category: Russo-Marie F]]
[[Category: CA]]
[[Category: annexin family]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:03:36 2007''

Latest revision as of 06:33, 7 February 2024

THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V

1axn, resolution 1.78Å

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