2mx6: Difference between revisions
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==Complex structure of Dvl PDZ domain with ligand== | ==Complex structure of Dvl PDZ domain with ligand== | ||
<StructureSection load='2mx6' size='340' side='right'caption='[[2mx6 | <StructureSection load='2mx6' size='340' side='right'caption='[[2mx6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2mx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MX6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx6 OCA], [https://pdbe.org/2mx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx6 OCA], [https://pdbe.org/2mx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Zhang X]] | ||
[[Category: | [[Category: Zheng JJ]] | ||
Latest revision as of 08:19, 30 October 2024
Complex structure of Dvl PDZ domain with ligand
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