5qdc: Difference between revisions
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==Crystal structure of BACE complex with BMC019 hydrolyzed== | ==Crystal structure of BACE complex with BMC019 hydrolyzed== | ||
<StructureSection load='5qdc' size='340' side='right'caption='[[5qdc]]' scene=''> | <StructureSection load='5qdc' size='340' side='right'caption='[[5qdc]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDC FirstGlance]. <br> | <table><tr><td colspan='2'>[[5qdc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdc OCA], [https://pdbe.org/5qdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdc RCSB], [https://www.ebi.ac.uk/pdbsum/5qdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdc ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E77:(4S)-4-[(1R)-1,2-dihydroxyethyl]-N,N-dimethyl-2-oxo-11,16-dioxa-3-azatricyclo[15.3.1.1~6,10~]docosa-1(21),6(22),7,9,17,19-hexaene-19-carboxamide'>E77</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdc OCA], [https://pdbe.org/5qdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdc RCSB], [https://www.ebi.ac.uk/pdbsum/5qdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rondeau | [[Category: Burley SK]] | ||
[[Category: Rondeau JM]] | |||
[[Category: Shao C]] | |||
[[Category: Yang H]] | |||
Latest revision as of 08:51, 7 February 2024
Crystal structure of BACE complex with BMC019 hydrolyzed
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