6z5e: Difference between revisions
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New page: ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004093== <StructureSection load='6z5e' size='340' side='right'caption='6z5e' scene=''> == Structural highlights == ... |
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==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004093== | ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004093== | ||
<StructureSection load='6z5e' size='340' side='right'caption='[[6z5e]]' scene=''> | <StructureSection load='6z5e' size='340' side='right'caption='[[6z5e]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z5E FirstGlance]. <br> | <table><tr><td colspan='2'>[[6z5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z5E FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5e OCA], [https://pdbe.org/6z5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5e RCSB], [https://www.ebi.ac.uk/pdbsum/6z5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5e ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q8K:11-cyclopropyl-14-(2-hydroxyethyl)-8,11,14,18,19,22-hexazatetracyclo[13.5.2.12,6.018,21]tricosa-1(21),2(23),3,5,15(22),16,19-heptaen-7-one'>Q8K</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5e OCA], [https://pdbe.org/6z5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5e RCSB], [https://www.ebi.ac.uk/pdbsum/6z5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5e ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref> | |||
==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Benderitter P]] | [[Category: Benderitter P]] | ||
Latest revision as of 13:42, 24 January 2024
Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004093
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