2ndi: Difference between revisions

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==Solution structure of the toxin ISTX-I from Ixodes scapularis==

== Structural highlights ==

<table><tr><td colspan='2'>[[2ndi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Black-legged_tick Black-legged tick~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDI FirstGlance]. <br>

<table><tr><td colspan='2'>[[2ndi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDI FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndi OCA], [https://pdbe.org/2ndi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndi RCSB], [https://www.ebi.ac.uk/pdbsum/2ndi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndi ProSAT]</span></td></tr>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndi OCA], [https://pdbe.org/2ndi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndi RCSB], [https://www.ebi.ac.uk/pdbsum/2ndi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndi ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ISTX_IXOSC ISTX_IXOSC] By inhibiting Nav1.7/SCN9A sodium channel, may prevent signal transmission caused by tick penetration and the blood taken, allowing the tick to avoid discovery (PubMed:27407029). Weakly and specifically inhibits Nav1.7/SCN9A (IC(50)=1.6 uM) (PubMed:27407029). Significantly shifts the steady-state inactivation curve of the Nav1.7/SCN9A in the hyperpolarized direction (PubMed:27407029). Does not induce changes to I-V curve and conductance-voltage relationship (PubMed:27407029).<ref>PMID:27407029</ref>

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

[[Category: ~~Black-legged tick~~]]

[[Category: Ixodes scapularis]]

[[Category: Large Structures]]

[[Category: Hu, K]]

[[Category: Hu K]]

~~[[Category: Toxin]]~~

~~[[Category: Toxin peptide~~]]

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 ==Solution structure of the toxin ISTX-I from Ixodes scapularis==
-<StructureSection load='2ndi' size='340' side='right'caption='[[2ndi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2ndi' size='340' side='right'caption='[[2ndi]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ndi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Black-legged_tick Black-legged tick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ndi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDI FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndi OCA], [https://pdbe.org/2ndi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndi RCSB], [https://www.ebi.ac.uk/pdbsum/2ndi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndi ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndi OCA], [https://pdbe.org/2ndi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndi RCSB], [https://www.ebi.ac.uk/pdbsum/2ndi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndi ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ISTX_IXOSC ISTX_IXOSC] By inhibiting Nav1.7/SCN9A sodium channel, may prevent signal transmission caused by tick penetration and the blood taken, allowing the tick to avoid discovery (PubMed:27407029). Weakly and specifically inhibits Nav1.7/SCN9A (IC(50)=1.6 uM) (PubMed:27407029). Significantly shifts the steady-state inactivation curve of the Nav1.7/SCN9A in the hyperpolarized direction (PubMed:27407029). Does not induce changes to I-V curve and conductance-voltage relationship (PubMed:27407029).<ref>PMID:27407029</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Black-legged tick]]
+[[Category: Ixodes scapularis]]
 [[Category: Large Structures]]
-[[Category: Hu, K]]
+[[Category: Hu K]]
-[[Category: Toxin]]
-[[Category: Toxin peptide]]