7ezh: Difference between revisions
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New page: '''Unreleased structure''' The entry 7ezh is ON HOLD until Paper Publication Authors: Liu, Q.F., Yang, D.H., Zhuang, Y.W., Croll, T.I., Cai, X.Q., Duan, J., Dai, A.T., Yin, W.C., Ye, C.... |
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The | ==Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex== | ||
<StructureSection load='7ezh' size='340' side='right'caption='[[7ezh]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ezh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EZH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ezh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ezh OCA], [https://pdbe.org/7ezh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ezh RCSB], [https://www.ebi.ac.uk/pdbsum/7ezh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ezh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
==See Also== | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Cai XQ]] | ||
[[Category: | [[Category: Croll TI]] | ||
[[Category: | [[Category: Dai AT]] | ||
[[Category: | [[Category: Duan J]] | ||
[[Category: | [[Category: Jiang Y]] | ||
[[Category: Yang | [[Category: Liu QF]] | ||
[[Category: | [[Category: Wang MW]] | ||
[[Category: | [[Category: Wu BL]] | ||
[[Category: Zhao | [[Category: Xu HE]] | ||
[[Category: | [[Category: Yang DH]] | ||
[[Category: Ye CY]] | |||
[[Category: Yin WC]] | |||
[[Category: Zhao Q]] | |||
[[Category: Zhou FL]] | |||
[[Category: Zhuang YW]] | |||
Latest revision as of 13:34, 6 November 2024
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex
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