7ots: Difference between revisions

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Bots, Bureaucrats, journal, Administrators
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'''Unreleased structure'''


The entry 7ots is ON HOLD
==Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside==
<StructureSection load='7ots' size='340' side='right'caption='[[7ots]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ots]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ots OCA], [https://pdbe.org/7ots PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ots RCSB], [https://www.ebi.ac.uk/pdbsum/7ots PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ots ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ABHD6_HUMAN ABHD6_HUMAN] Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).[UniProtKB:Q8R2Y0]<ref>PMID:22969151</ref> <ref>PMID:26491015</ref>


Authors: Nawrotek, A., Talagas, A., Vuillard, L., Miallau, L.
==See Also==
 
*[[Lipase 3D Structures|Lipase 3D Structures]]
Description: Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Talagas, A]]
__TOC__
[[Category: Miallau, L]]
</StructureSection>
[[Category: Nawrotek, A]]
[[Category: Homo sapiens]]
[[Category: Vuillard, L]]
[[Category: Large Structures]]
[[Category: Miallau L]]
[[Category: Nawrotek A]]
[[Category: Talagas A]]
[[Category: Vuillard L]]
Retrieved from "https://proteopedia.org/7ots"