7ox4: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7ox4 is ~~ON HOLD~~

==Mouse interleukin-9 in complex with Fab 35D8.==

== Structural highlights ==

<table><tr><td colspan='2'>[[7ox4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OX4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7OX4 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7ox4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ox4 OCA], [https://pdbe.org/7ox4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ox4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ox4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ox4 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/IL9_MOUSE IL9_MOUSE] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327).<ref>PMID:10464327</ref> <ref>PMID:11070175</ref> <ref>PMID:12704113</ref> <ref>PMID:19433802</ref> <ref>PMID:2145361</ref> <ref>PMID:7718508</ref>

~~Authors~~:

==See Also==

*[[Interleukin 3D structures|Interleukin 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: De Vos T]]

[[Category: Savvides SN]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ox4 is ON HOLD
+==Mouse interleukin-9 in complex with Fab 35D8.==
+<StructureSection load='7ox4' size='340' side='right'caption='[[7ox4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ox4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OX4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ox4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ox4 OCA], [https://pdbe.org/7ox4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ox4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ox4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ox4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL9_MOUSE IL9_MOUSE] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327).<ref>PMID:10464327</ref> <ref>PMID:11070175</ref> <ref>PMID:12704113</ref> <ref>PMID:19433802</ref> <ref>PMID:2145361</ref> <ref>PMID:7718508</ref>
-Authors:
+==See Also==
+*[[Interleukin 3D structures|Interleukin 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: De Vos T]]
+[[Category: Savvides SN]]