7oy3: Difference between revisions
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==Crystal structure of depupylase Dop in complex with phosphorylated Pup and ADP== | |||
<StructureSection load='7oy3' size='340' side='right'caption='[[7oy3]], [[Resolution|resolution]] 1.78Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7oy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidothermus_cellulolyticus Acidothermus cellulolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=VHF:(2~{S})-2-azanyl-5-oxidanylidene-5-phosphonooxy-pentanoic+acid'>VHF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy3 OCA], [https://pdbe.org/7oy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy3 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DOP_ACIC1 DOP_ACIC1] Displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins. Is also able to catalyze the deamidation of the C-terminal glutamine to glutamate in a variant of the prokaryotic ubiquitin-like protein Pup; however, since Pup from A.cellulolyticus possesses a C-terminal glutamate, this deamidase activity may be of no significance in vivo.<ref>PMID:22910360</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Acidothermus cellulolyticus]] | |||
[[Category: Large Structures]] | |||
[[Category: Cui H]] | |||
Latest revision as of 07:53, 7 February 2024
Crystal structure of depupylase Dop in complex with phosphorylated Pup and ADP
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