7etj: Difference between revisions
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==== | ==C5 portal vertex in the partially-enveloped virion capsid== | ||
<StructureSection load='7etj' size='340' side='right'caption='[[7etj]]' scene=''> | <StructureSection load='7etj' size='340' side='right'caption='[[7etj]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7etj]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ETJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ETJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7etj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7etj OCA], [https://pdbe.org/7etj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7etj RCSB], [https://www.ebi.ac.uk/pdbsum/7etj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7etj ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7etj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7etj OCA], [https://pdbe.org/7etj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7etj RCSB], [https://www.ebi.ac.uk/pdbsum/7etj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7etj ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q6RXF2_HCMV Q6RXF2_HCMV] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry. | |||
Structural basis for genome packaging, retention, and ejection in human cytomegalovirus.,Li Z, Pang J, Dong L, Yu X Nat Commun. 2021 Jul 27;12(1):4538. doi: 10.1038/s41467-021-24820-3. PMID:34315863<ref>PMID:34315863</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7etj" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human betaherpesvirus 5]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z | [[Category: Li Z]] | ||
[[Category: Yu X]] | |||
Latest revision as of 06:16, 21 November 2024
C5 portal vertex in the partially-enveloped virion capsid
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