7p42: Difference between revisions
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==Crystal structure of IpgC in complex with a follow-up compound based on J2== | |||
<StructureSection load='7p42' size='340' side='right'caption='[[7p42]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7p42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P42 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5I8:2-(4,6-dimethylpyrimidin-2-yl)-3H-isoindol-1-imine'>5I8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
[[Category: Gardonyi | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p42 OCA], [https://pdbe.org/7p42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p42 RCSB], [https://www.ebi.ac.uk/pdbsum/7p42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p42 ProSAT]</span></td></tr> | ||
[[Category: Heine | </table> | ||
[[Category: Klebe | == Function == | ||
[https://www.uniprot.org/uniprot/IPGC_SHIFL IPGC_SHIFL] Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Shigella flexneri]] | |||
[[Category: Gardonyi M]] | |||
[[Category: Heine A]] | |||
[[Category: Klebe G]] | |||
Latest revision as of 13:01, 1 February 2024
Crystal structure of IpgC in complex with a follow-up compound based on J2
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