7rkf: Difference between revisions

Latest revision as of 11:27, 23 October 2024

Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state

Structural highlights

7rkf is a 6 chain structure with sequence from Homo sapiens, Human betaherpesvirus 5 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4Å
Ligands:	GDP, NAG, PCA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GNA11_HUMAN Phakomatosis cesioflammea;Uveal melanoma;Phakomatosis cesiomarmorata;Autosomal dominant hypocalcemia;Familial hypocalciuric hypercalcemia type 2;Cutis marmorata telangiectatica congenita. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

Function

GNA11_HUMAN Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:31073061). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:31073061). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity).[UniProtKB:P21278]^[1] ^[2]

References

↑ Alvarez-Curto E, Inoue A, Jenkins L, Raihan SZ, Prihandoko R, Tobin AB, Milligan G. Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. J Biol Chem. 2016 Dec 30;291(53):27147-27159. PMID:27852822 doi:10.1074/jbc.M116.754887
↑ Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188. PMID:31073061 doi:https://dx.doi.org/10.1126/science.aaw5188

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OCA

[1] Alvarez-Curto E, Inoue A, Jenkins L, Raihan SZ, Prihandoko R, Tobin AB, Milligan G. Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. J Biol Chem. 2016 Dec 30;291(53):27147-27159. PMID:27852822 doi:10.1074/jbc.M116.754887

[2] Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188. PMID:31073061 doi:https://dx.doi.org/10.1126/science.aaw5188

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7rkf is ON HOLD
+==Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state==
+<StructureSection load='7rkf' size='340' side='right'caption='[[7rkf]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7rkf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RKF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rkf OCA], [https://pdbe.org/7rkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rkf RCSB], [https://www.ebi.ac.uk/pdbsum/7rkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rkf ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GNA11_HUMAN GNA11_HUMAN] Phakomatosis cesioflammea;Uveal melanoma;Phakomatosis cesiomarmorata;Autosomal dominant hypocalcemia;Familial hypocalciuric hypercalcemia type 2;Cutis marmorata telangiectatica congenita. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/GNA11_HUMAN GNA11_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:31073061). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:31073061). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity).[UniProtKB:P21278]<ref>PMID:27852822</ref> <ref>PMID:31073061</ref>
-Authors:
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
-Description:
+*[[Transducin 3D structures|Transducin 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human betaherpesvirus 5]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Garcia KC]]
+[[Category: Kobilka BK]]
+[[Category: Maeda S]]
+[[Category: Qu Q]]
+[[Category: Skiniotis G]]
+[[Category: Tsutsumi N]]

7rkf: Difference between revisions

Latest revision as of 11:27, 23 October 2024

Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state

Structural highlights

Disease

Function

See Also

References

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