1g1e: Difference between revisions

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==NMR STRUCTURE OF THE HUMAN MAD1 TRANSREPRESSION DOMAIN SID IN COMPLEX WITH MAMMALIAN SIN3A PAH2 DOMAIN==

== Structural highlights ==

<table><tr><td colspan='2'>[[1g1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1E OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1G1E FirstGlance].

<table><tr><td colspan='2'>[[1g1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1E OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1G1E FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1g1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g1e OCA], [https://pdbe.org/1g1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g1e RCSB], [https://www.ebi.ac.uk/pdbsum/1g1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g1e ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1g1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g1e OCA], [https://pdbe.org/1g1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g1e RCSB], [https://www.ebi.ac.uk/pdbsum/1g1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g1e ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/~~SIN3A_MOUSE SIN3A_MOUSE~~]~~] Acts as a transcriptional~~ repressor. ~~Corepressor for REST. Interacts~~ with ~~MXI1~~ to ~~repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1~~-~~MAX heterodimers to repress transcription by tethering SIN3A to~~ DNA. ~~Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation~~.~~<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>~~

[https://www.uniprot.org/uniprot/MAD1_HUMAN MAD1_HUMAN] Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Lk3 transgenic mice~~]]

[[Category: Mus musculus]]

[[Category: Brubaker, K]]

[[Category: Brubaker K]]

[[Category: Cowley~~, S M~~]]

[[Category: Cowley SM]]

[[Category: Eisenman~~, R N~~]]

[[Category: Eisenman RN]]

[[Category: Huang, K]]

[[Category: Huang K]]

[[Category: Radhakrishnan, I]]

[[Category: Radhakrishnan I]]

~~[[Category: Four-helix bundle]]~~

~~[[Category: Protein-peptide complex]]~~

~~[[Category: Transcription~~]]

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@@ Line 1: / Line 1: @@
 ==NMR STRUCTURE OF THE HUMAN MAD1 TRANSREPRESSION DOMAIN SID IN COMPLEX WITH MAMMALIAN SIN3A PAH2 DOMAIN==
-<StructureSection load='1g1e' size='340' side='right'caption='[[1g1e]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+<StructureSection load='1g1e' size='340' side='right'caption='[[1g1e]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1g1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G1E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1g1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G1E FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g1e OCA], [https://pdbe.org/1g1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g1e RCSB], [https://www.ebi.ac.uk/pdbsum/1g1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g1e ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g1e OCA], [https://pdbe.org/1g1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g1e RCSB], [https://www.ebi.ac.uk/pdbsum/1g1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g1e ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>
+[https://www.uniprot.org/uniprot/MAD1_HUMAN MAD1_HUMAN] Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Brubaker, K]]
+[[Category: Brubaker K]]
-[[Category: Cowley, S M]]
+[[Category: Cowley SM]]
-[[Category: Eisenman, R N]]
+[[Category: Eisenman RN]]
-[[Category: Huang, K]]
+[[Category: Huang K]]
-[[Category: Radhakrishnan, I]]
+[[Category: Radhakrishnan I]]
-[[Category: Four-helix bundle]]
-[[Category: Protein-peptide complex]]
-[[Category: Transcription]]