1i7s: Difference between revisions

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<StructureSection load='1i7s' size='340' side='right'caption='[[1i7s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1i7s' size='340' side='right'caption='[[1i7s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1i7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I7S FirstGlance]. <br>
<table><tr><td colspan='2'>[[1i7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I7S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Anthranilate_synthase Anthranilate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.27 4.1.3.27] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7s OCA], [https://pdbe.org/1i7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i7s RCSB], [https://www.ebi.ac.uk/pdbsum/1i7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i7s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7s OCA], [https://pdbe.org/1i7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i7s RCSB], [https://www.ebi.ac.uk/pdbsum/1i7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i7s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRPE_SERMA TRPE_SERMA]] Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (Probable). [[https://www.uniprot.org/uniprot/TRPG_SERMA TRPG_SERMA]] Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (Probable).<ref>PMID:11371633</ref> 
[https://www.uniprot.org/uniprot/TRPE_SERMA TRPE_SERMA] Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (Probable).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anthranilate synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kim, C]]
[[Category: Serratia marcescens]]
[[Category: Mills, S E]]
[[Category: Kim C]]
[[Category: Nguyen-Huu, X]]
[[Category: Mills SE]]
[[Category: Spraggon, G]]
[[Category: Nguyen-Huu X]]
[[Category: Yanofsky, C]]
[[Category: Spraggon G]]
[[Category: Yee, M C]]
[[Category: Yanofsky C]]
[[Category: Conformational change]]
[[Category: Yee M-C]]
[[Category: End product inhibition]]
[[Category: Lyase]]
[[Category: Tryptophan binding]]
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