1j3j: Difference between revisions

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<StructureSection load='1j3j' size='340' side='right'caption='[[1j3j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1j3j' size='340' side='right'caption='[[1j3j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1j3j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J3J FirstGlance]. <br>
<table><tr><td colspan='2'>[[1j3j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J3J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j3i|1j3i]], [[1j3k|1j3k]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3j OCA], [https://pdbe.org/1j3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j3j RCSB], [https://www.ebi.ac.uk/pdbsum/1j3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j3j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3j OCA], [https://pdbe.org/1j3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j3j RCSB], [https://www.ebi.ac.uk/pdbsum/1j3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j3j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]  
[https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Plafa]]
[[Category: Plasmodium falciparum]]
[[Category: Chitnumsub, P]]
[[Category: Chitnumsub P]]
[[Category: Kamchonwongpaisan, S]]
[[Category: Kamchonwongpaisan S]]
[[Category: Sirawaraporn, W]]
[[Category: Sirawaraporn W]]
[[Category: Taylor, P]]
[[Category: Taylor P]]
[[Category: Vanichtanankul, J]]
[[Category: Vanichtanankul J]]
[[Category: Walkinshaw, M]]
[[Category: Walkinshaw M]]
[[Category: Yuthavong, Y]]
[[Category: Yuthavong Y]]
[[Category: Yuvaniyama, J]]
[[Category: Yuvaniyama J]]
[[Category: Bifunctional]]
[[Category: Oxidoreductase]]
[[Category: Transferase]]
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