Lipase lid morph: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Karsten Theis (talk | contribs)
No edit summary
Karsten Theis (talk | contribs)
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 16: Line 16:
*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />).
*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />).


An alternate morph<ref>This is a rigid body morph based on the superoposition in PDB file is [[Image:1TRH_1LPM.pdb]] and created by the [[Jmol/Storymorph|Storymorph script]] on the fly.</ref> shows a <scene name='49/493694/Storymorph/1'>different path</scene> between the same initial and final experimental structures. The position of the inhibitor in the 1lpm structure is shown throughout; it would clash with the conformation of the lid in the 1trh structures, showing that closed lid and inhibitor binding are mutually exclusive.
=== Rigid body morph ===
 
An <scene name='49/493694/Storymorph/1'>alternate morph</scene> shows a different path between the same initial and final experimental structures <ref>This is a rigid body morph based on the superposition in PDB file [[Image:1TRH_1LPM.pdb]]. It is created by the [[Jmol/Storymorph|Storymorph script]] on the fly.</ref>. The position of the inhibitor in the 1lpm structure is shown throughout; it would clash with the conformation of the lid in the 1trh structures, showing that closed lid and inhibitor binding are mutually exclusive.


<jmol>
<jmol>