1bo1: Difference between revisions

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New page: left|200px<br /> <applet load="1bo1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bo1, resolution 3.0Å" /> '''PHOSPHATIDYLINOSITOL...
 
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[[Image:1bo1.gif|left|200px]]<br />
<applet load="1bo1" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bo1, resolution 3.0&Aring;" />
'''PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA'''<br />


==Overview==
==PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA==
Phosphoinositide kinases play central roles in signal transduction by, phosphorylating the inositol ring at specific positions. The structure of, one such enzyme, type IIbeta phosphatidylinositol phosphate kinase, reveals a protein kinase ATP-binding core and demonstrates that all, phosphoinositide kinases belong to one superfamily. The enzyme is a, disc-shaped homodimer with a 33 x 48 A basic flat face that suggests an, electrostatic mechanism for plasma membrane targeting. Conserved basic, residues form a putative phosphatidylinositol phosphate specificity site., The substrate-binding site is open on one side, consistent with dual, specificity for phosphatidylinositol 3- and 5-phosphates. A modeled, complex with membrane-bound substrate and ATP shows how a phosphoinositide, kinase can phosphorylate its substrate in situ at the membrane interface.
<StructureSection load='1bo1' size='340' side='right'caption='[[1bo1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1bo1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BO1 FirstGlance]. <br>
1BO1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/1-phosphatidylinositol-4-phosphate_5-kinase 1-phosphatidylinositol-4-phosphate 5-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.68 2.7.1.68] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BO1 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo1 OCA], [https://pdbe.org/1bo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bo1 ProSAT]</span></td></tr>
==Reference==
</table>
Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation., Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH, Cell. 1998 Sep 18;94(6):829-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9753329 9753329]
== Function ==
[[Category: 1-phosphatidylinositol-4-phosphate 5-kinase]]
[https://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1bo1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bo1 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Anderson, R.A.]]
[[Category: Anderson RA]]
[[Category: Boronenkov, I.V.]]
[[Category: Boronenkov IV]]
[[Category: Hurley, J.H.]]
[[Category: Hurley JH]]
[[Category: Misra, S.]]
[[Category: Misra S]]
[[Category: Rao, V.D.]]
[[Category: Rao VD]]
[[Category: lipid signaling]]
 
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