7phj: Difference between revisions
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New page: '''Unreleased structure''' The entry 7phj is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-... |
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==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria== | |||
<StructureSection load='7phj' size='340' side='right'caption='[[7phj]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7phj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PHJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PX:(2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide'>7PX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7phj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7phj OCA], [https://pdbe.org/7phj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7phj RCSB], [https://www.ebi.ac.uk/pdbsum/7phj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7phj ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[ | == Function == | ||
[[Category: Leonard | [https://www.uniprot.org/uniprot/LPXC_ECOLI LPXC_ECOLI] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.[HAMAP-Rule:MF_00388]<ref>PMID:10026271</ref> <ref>PMID:8530464</ref> <ref>PMID:8824222</ref> <ref>PMID:18289052</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Lamers MBAC]] | |||
[[Category: Leonard PM]] | |||
[[Category: Pallin TD]] | |||
[[Category: Ryan MD]] | |||
Latest revision as of 07:54, 7 February 2024
LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
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