7phn: Difference between revisions
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New page: '''Unreleased structure''' The entry 7phn is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-... |
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==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria== | |||
<StructureSection load='7phn' size='340' side='right'caption='[[7phn]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7phn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PHN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PX:(2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide'>7PX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7phn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7phn OCA], [https://pdbe.org/7phn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7phn RCSB], [https://www.ebi.ac.uk/pdbsum/7phn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7phn ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[ | == Function == | ||
[[Category: Leonard | [https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa PAO1]] | |||
[[Category: Lamers MBAC]] | |||
[[Category: Leonard PM]] | |||
[[Category: Pallin TD]] | |||
[[Category: Ryan MD]] | |||
Latest revision as of 07:54, 7 February 2024
LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
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