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<StructureSection load='5xds' size='340' side='right'caption='[[5xds]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='5xds' size='340' side='right'caption='[[5xds]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xds]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XDS FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xds]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XDS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=83O:(2S)-2-azanyl-3-(4H-1,2,4-triazol-3-yl)propanoic+acid'>83O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hisB, Rv1601, MTCY336.03c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=83O:(2S)-2-azanyl-3-(4H-1,2,4-triazol-3-yl)propanoic+acid'>83O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xds OCA], [https://pdbe.org/5xds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xds RCSB], [https://www.ebi.ac.uk/pdbsum/5xds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xds ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xds OCA], [https://pdbe.org/5xds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xds RCSB], [https://www.ebi.ac.uk/pdbsum/5xds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xds ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIS7_MYCTU HIS7_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Imidazoleglycerol-phosphate dehydratase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ahangar, M S]]
[[Category: Ahangar MS]]
[[Category: Jha, B]]
[[Category: Jha B]]
[[Category: Kumar, B B]]
[[Category: Kumar BB]]
[[Category: Kumar, D]]
[[Category: Kumar D]]
[[Category: Drug target]]
[[Category: Imidazoleglycerol phosphate dehydratase]]
[[Category: Lyase-lyase inhibitor complex]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Tuberculosis]]

Latest revision as of 08:00, 22 November 2023

Crystal structure of Mycobacterium tuberculosis HisB bound with an inhibitor

5xds, resolution 1.75Å

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