7vce: Difference between revisions
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==Structural studies of human inositol monophosphatase-1 inhibition by ebselen== | |||
<StructureSection load='7vce' size='340' side='right'caption='[[7vce]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VCE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vce OCA], [https://pdbe.org/7vce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vce RCSB], [https://www.ebi.ac.uk/pdbsum/7vce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vce ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref> | |||
==See Also== | |||
*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Abuhammad A]] | |||
[[Category: Churchill GC]] | |||
[[Category: Laurieri N]] | |||
[[Category: Lowe ED]] | |||
[[Category: McDonough MA]] | |||
[[Category: Rice A]] | |||
[[Category: Singh N]] | |||
Latest revision as of 17:22, 29 November 2023
Structural studies of human inositol monophosphatase-1 inhibition by ebselen
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