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==[PRO7,13] AA-CONOTOXIN PIVA, NMR, 12 STRUCTURES==
==[PRO7,13] AA-CONOTOXIN PIVA, NMR, 12 STRUCTURES==
<StructureSection load='1p1p' size='340' side='right'caption='[[1p1p]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
<StructureSection load='1p1p' size='340' side='right'caption='[[1p1p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conpu Conpu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P1P FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_purpurascens Conus purpurascens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P1P FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p1p OCA], [https://pdbe.org/1p1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p1p RCSB], [https://www.ebi.ac.uk/pdbsum/1p1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p1p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p1p OCA], [https://pdbe.org/1p1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p1p RCSB], [https://www.ebi.ac.uk/pdbsum/1p1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p1p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CA4A_CONPU CA4A_CONPU]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin has higher affinity for the adult subtype (alpha-1/beta-1/gamma/delta subunits) (IC(50)=2.3 nM) of the receptor than for the fetal subtype (alpha-1/beta-1/epsilon/delta subunits) (IC(50)=22 nM).<ref>PMID:16430227</ref>
[https://www.uniprot.org/uniprot/CA4A_CONPU CA4A_CONPU] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin has higher affinity for the adult subtype (alpha-1/beta-1/gamma/delta subunits) (IC(50)=2.3 nM) of the receptor than for the fetal subtype (alpha-1/beta-1/epsilon/delta subunits) (IC(50)=22 nM).<ref>PMID:16430227</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conpu]]
[[Category: Conus purpurascens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gray, W R]]
[[Category: Gray WR]]
[[Category: Han, K H]]
[[Category: Han K-H]]
[[Category: Hwang, K J]]
[[Category: Hwang K-J]]
[[Category: Kim, S K]]
[[Category: Kim S-K]]
[[Category: Kim, S M]]
[[Category: Kim S-M]]
[[Category: Olivera, B M]]
[[Category: Olivera BM]]
[[Category: Rivier, J]]
[[Category: Rivier J]]
[[Category: Shon, K J]]
[[Category: Shon KJ]]
[[Category: Acetylcholine receptor binding]]
[[Category: Conotoxin]]
[[Category: Neurotoxin]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/1p1p"