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[[Image:1f8t.jpg|left|200px]]
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{{STRUCTURE_1f8t|  PDB=1f8t  |  SCENE=  }}
'''FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE'''


==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE==
<StructureSection load='1f8t' size='340' side='right'caption='[[1f8t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8t OCA], [https://pdbe.org/1f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8t RCSB], [https://www.ebi.ac.uk/pdbsum/1f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8t ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.


==Overview==
[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms],Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ Bioorg Khim. 2000 Aug;26(8):571-8. PMID:11040993<ref>PMID:11040993</ref>
The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA].
</div>
<div class="pdbe-citations 1f8t" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms], Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ, Bioorg Khim. 2000 Aug;26(8):571-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11040993 11040993]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
[[Category: Afonin, P V.]]
== References ==
[[Category: Fokin, A V.]]
<references/>
[[Category: Mareeva, T I.]]
__TOC__
[[Category: Mikhailova, I I.]]
</StructureSection>
[[Category: Tsygannik, I N.]]
[[Category: Large Structures]]
[[Category: Antigen-binding fragment]]
[[Category: Mus musculus]]
[[Category: Crystal]]
[[Category: Afonin PV]]
[[Category: Interleukin-2]]
[[Category: Fokin AV]]
[[Category: Monoclonal antibody]]
[[Category: Mareeva TI]]
[[Category: X-ray analysis]]
[[Category: Mikhailova II]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:02:23 2008''
[[Category: Tsygannik IN]]
Retrieved from "https://proteopedia.org/1f8t"