7vf6: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 7vf6 is ON HOLD Authors: Description: Category: Unreleased Structures |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==The crystal structure of PurZ0== | ||
<StructureSection load='7vf6' size='340' side='right'caption='[[7vf6]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vf6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gordonia_phage_Archimedes Gordonia phage Archimedes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.703Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf6 OCA], [https://pdbe.org/7vf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A7L7SI10_9CAUD A0A7L7SI10_9CAUD] Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP. dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes.[HAMAP-Rule:MF_04166] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gordonia phage Archimedes]] | |||
[[Category: Large Structures]] | |||
[[Category: Tong Y]] | |||
[[Category: Zhang Y]] | |||
