1t2m: Difference between revisions

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==Solution Structure Of The Pdz Domain Of AF-6==

== Structural highlights ==

<table><tr><td colspan='2'>[[1t2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2M OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1T2M FirstGlance].

<table><tr><td colspan='2'>[[1t2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2M OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1T2M FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1t2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2m OCA], [https://pdbe.org/1t2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2m RCSB], [https://www.ebi.ac.uk/pdbsum/1t2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2m ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1t2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2m OCA], [https://pdbe.org/1t2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2m RCSB], [https://www.ebi.ac.uk/pdbsum/1t2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2m ProSAT]</td></tr>

</table>

== Disease ==

[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

== Function ==

[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Huang~~, A D~~]]

[[Category: Huang AD]]

[[Category: Shi~~, Y Y~~]]

[[Category: Shi YY]]

[[Category: Wu~~, J H~~]]

[[Category: Wu JH]]

[[Category: Xu~~, Y Q~~]]

[[Category: Xu YQ]]

[[Category: Zhou, H]]

[[Category: Zhou H]]

~~[[Category: Chromosomal translocation]]~~

~~[[Category: Protein binding]]~~

~~[[Category: Proto-oncogene~~]]

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@@ Line 1: / Line 1: @@
 ==Solution Structure Of The Pdz Domain Of AF-6==
-<StructureSection load='1t2m' size='340' side='right'caption='[[1t2m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1t2m' size='340' side='right'caption='[[1t2m]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1t2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1t2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2M FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2m OCA], [https://pdbe.org/1t2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2m RCSB], [https://www.ebi.ac.uk/pdbsum/1t2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2m ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2m OCA], [https://pdbe.org/1t2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2m RCSB], [https://www.ebi.ac.uk/pdbsum/1t2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2m ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
+[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
 == Function ==
-[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
+[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 34: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Huang, A D]]
+[[Category: Huang AD]]
-[[Category: Shi, Y Y]]
+[[Category: Shi YY]]
-[[Category: Wu, J H]]
+[[Category: Wu JH]]
-[[Category: Xu, Y Q]]
+[[Category: Xu YQ]]
-[[Category: Zhou, H]]
+[[Category: Zhou H]]
-[[Category: Chromosomal translocation]]
-[[Category: Protein binding]]
-[[Category: Proto-oncogene]]