1t3c: Difference between revisions

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<StructureSection load='1t3c' size='340' side='right'caption='[[1t3c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1t3c' size='340' side='right'caption='[[1t3c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3C FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t3a|1t3a]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3c OCA], [https://pdbe.org/1t3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3c RCSB], [https://www.ebi.ac.uk/pdbsum/1t3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3c OCA], [https://pdbe.org/1t3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3c RCSB], [https://www.ebi.ac.uk/pdbsum/1t3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/BXE_CLOBO BXE_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile-181 bond in SNAP-25.  
[https://www.uniprot.org/uniprot/BXE_CLOBO BXE_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile-181 bond in SNAP-25.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Clostridium botulinum]]
[[Category: Bontoxilysin]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Agarwal, R]]
[[Category: Agarwal R]]
[[Category: Binz, T]]
[[Category: Binz T]]
[[Category: Eswaramoorthy, S]]
[[Category: Eswaramoorthy S]]
[[Category: Kumaran, D]]
[[Category: Kumaran D]]
[[Category: Swaminathan, S]]
[[Category: Swaminathan S]]
[[Category: Catalytic domain]]
[[Category: Clostridium botulinum]]
[[Category: E212q mutant]]
[[Category: Hydrolase]]
[[Category: Light chain]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/1t3c"