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==SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES==
==SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES==
<StructureSection load='1tba' size='340' side='right'caption='[[1tba]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='1tba' size='340' side='right'caption='[[1tba]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBA FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBA FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tba OCA], [https://pdbe.org/1tba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tba RCSB], [https://www.ebi.ac.uk/pdbsum/1tba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tba ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tba OCA], [https://pdbe.org/1tba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tba RCSB], [https://www.ebi.ac.uk/pdbsum/1tba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tba ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TAF1_DROME TAF1_DROME]] TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. The C-terminal Ser/Thr kinase domain phosphorylates histone H2B at 'Ser-33', which may contribute to transcriptional activation during embryogenesis. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.<ref>PMID:8504928</ref> <ref>PMID:8625415</ref> <ref>PMID:15143281</ref> <ref>PMID:9741622</ref> [[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> 
[https://www.uniprot.org/uniprot/TAF1_DROME TAF1_DROME] TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. The C-terminal Ser/Thr kinase domain phosphorylates histone H2B at 'Ser-33', which may contribute to transcriptional activation during embryogenesis. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.<ref>PMID:8504928</ref> <ref>PMID:8625415</ref> <ref>PMID:15143281</ref> <ref>PMID:9741622</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Drosophila melanogaster]]
[[Category: Drome]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bagby, S]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Ikura, M]]
[[Category: Bagby S]]
[[Category: Ishima, R]]
[[Category: Ikura M]]
[[Category: Kay, L E]]
[[Category: Ishima R]]
[[Category: Kokubo, T]]
[[Category: Kay LE]]
[[Category: Liu, D]]
[[Category: Kokubo T]]
[[Category: Muhandiram, D R]]
[[Category: Liu D]]
[[Category: Nakatani, Y]]
[[Category: Muhandiram DR]]
[[Category: Tong, K I]]
[[Category: Nakatani Y]]
[[Category: Solution structure]]
[[Category: Tong KI]]
[[Category: Taf]]
[[Category: Tafii230]]
[[Category: Tbp]]
[[Category: Tfiid]]
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