Insulin receptor 3D structures: Difference between revisions

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310; Ectodomain 28-1382


**[[1irk]] – hIR TK domain – human<br />
**[[8u4b]] – hIR – human – Cryo EM<br />
**[[1i44]], [[1p14]] – hIR TK domain (mutant) <br />
**[[1irk]] – hIR TK domain <br />
**[[1i44]], [[1p14]], [[8dwn]] – hIR TK domain (mutant) <br />
**[[2hr7]] – hIR  domains 1-3<br />
**[[2hr7]] – hIR  domains 1-3<br />
**[[4xst]] – hIR  L1-CR domains <br />
**[[4xst]] – hIR  L1-CR domains <br />
**[[2mfr]] – hIR  transmembrane domain - NMR<br />
**[[2mfr]], [[7pht]] – hIR  transmembrane domain - NMR<br />


*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
*Insulin receptor complexes


**[[5j3h]] – hIR  L1-CR domains + antibody + peptide<br />
**[[5j3h]] – hIR  L1-CR domains + antibody + peptide<br />
**[[7kd6]] – hIR L1-CR domains + Scfv<br />
**[[4xss]] – hIR  L1-CR domains + insulin-like growth factor 1<br />
**[[4xss]] – hIR  L1-CR domains + insulin-like growth factor 1<br />
**[[3w12]] – hIR L1-CR domain + insulin + antibody<br />
**[[3w12]] – hIR L1-CR domain + insulin + antibody<br />
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**[[3bu5]], [[3bu6]] - hIR TK domain + ATP + peptide<br />
**[[3bu5]], [[3bu6]] - hIR TK domain + ATP + peptide<br />
**[[3bu3]] - hIR TK domain + peptide<br />
**[[3bu3]] - hIR TK domain + peptide<br />
**[[8dtl]], [[8dtm]] - hIR ectodomain + peptide – Cryo EM<br />
**[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br />
**[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br />
**[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br />
**[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br />
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**[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br />
**[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br />
**[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br />
**[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br />
**[[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin <ref>PMID:29512653</ref> <br />
**[[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin <br />
**[[6pxv]], [[6pxw]], [[6sof]], [[7bw7]], [[7bw8]], [[7bwa]] – hIR + insulin – Cryo EM<br />
**[[6pxv]], [[6pxw]], [[6sof]], [[7bw7]], [[7bw8]], [[7bwa]], [[7md4]], [[7md5]], [[7mqo]], [[7mqr]], [[7mqs]], [[7qid]], [[8guy]], [[8yyl]], [[8yys]], [[8yyt]] – hIR ectodomain + insulin – Cryo EM<br />
**[[6hn4]], [[6hn5]] - hIR + insulin <ref>PMID:30356040</ref><br />
**[[8eyx]] – hIR ectodomain (mutant) + insulin – Cryo EM<br />
**[[7u6d]], [[7u6e]] – hIR ectodomain + agonist – Cryo EM<br />
**[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] – hIR ectodomain + DNA – Cryo EM<br />
**[[9jf9]], [[9jfd]], [[9jhs]] – hIR 28-946 + DNA – Cryo EM<br />
**[[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7sl1]], [[7sl2]], [[7sl3]], [[7sl4]], [[7sl6]], [[7sl7]], [[7sth]], [[7sti]], [[7stj]], [[7stk]] – hIR + insulin – Cryo EM<br />
**[[8dtl]], [[8dtm]] – hIR + insulin mimetic – Cryo EM<br />
**[[7s8v]] – hIR ectodomain + IGF-I receptor – Cryo EM<br />
**[[8x06]], [[8x2m]], [[8xjs]], [[8xk1]], [[8xkm]], [[8xkr]] – hIR ectodomain + IGF-I  – Cryo EM<br />
**[[8u4c]], [[8u4e]], [[8vjc]], [[8ysz]] – hIR ectodomain + IGF-2 – Cryo EM<br />
**[[7s0q]] – hIR ectodomain + IGF-I receptor + IGF-I  – Cryo EM<br />
**[[6hn4]], [[6hn5]] - hIR + insulin <br />
**[[5kqv]] – hIR + insulin + antibody<br />
**[[5kqv]] – hIR + insulin + antibody<br />
**[[6vep]] – hIR + insulin + antibody – Cryo EM<br />
**[[6vep]] – hIR + insulin + antibody – Cryo EM<br />
**[[8eyx]], [[8eyy]], [[8ez0]] – mIR (mutant) + insulin – Cryo EM<br />
**[[6veq]] – IR + insulin + antibody – ''Conus geographus'' - Cryo EM<br />
**[[6veq]] – IR + insulin + antibody – ''Conus geographus'' - Cryo EM<br />


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