7kl8: Difference between revisions

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<StructureSection load='7kl8' size='340' side='right'caption='[[7kl8]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='7kl8' size='340' side='right'caption='[[7kl8]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7kl8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KL8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7kl8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KL8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J4:COENZYME+F420-3'>6J4</scene>, <scene name='pdbligand=F42:COENZYME+F420'>F42</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.469&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAB90_01754, DSI38_14865, E5M52_02625, ERS007663_00055, ERS007665_00099, ERS007670_00350, ERS007679_03028, ERS007681_00165, ERS007688_03909, ERS007703_00001, ERS007720_01803, ERS007722_00045, ERS007741_00109, ERS013471_00965, ERS023446_01350, ERS024276_03277, ERS027646_02383, ERS027659_01827, ERS027661_02140, ERS075361_00097, ERS094182_01470, F6W99_00117, FRD82_03855, SAMEA2683035_03185 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J4:COENZYME+F420-3'>6J4</scene>, <scene name='pdbligand=F42:COENZYME+F420'>F42</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kl8 OCA], [https://pdbe.org/7kl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kl8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kl8 OCA], [https://pdbe.org/7kl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kl8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FQR58_MYCTU FQR58_MYCTU] Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the membrane fraction of M.tuberculosis.<ref>PMID:23240649</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7kl8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7kl8" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nitroreductase 3D structures|Nitroreductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jackson, C J]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Lee, B M]]
[[Category: Jackson CJ]]
[[Category: Tan, L L]]
[[Category: Lee BM]]
[[Category: F420]]
[[Category: Tan LL]]
[[Category: Fdor]]
[[Category: Oxidoreductase]]
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