3h3j: Difference between revisions

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<StructureSection load='3h3j' size='340' side='right'caption='[[3h3j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3h3j' size='340' side='right'caption='[[3h3j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3h3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H3J FirstGlance]. <br>
<table><tr><td colspan='2'>[[3h3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H3J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d0o|3d0o]], [[3d4p|3d4p]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ldh1, SACOL0222 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3j OCA], [https://pdbe.org/3h3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3j RCSB], [https://www.ebi.ac.uk/pdbsum/3h3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3j OCA], [https://pdbe.org/3h3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3j RCSB], [https://www.ebi.ac.uk/pdbsum/3h3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LDH1_STAAC LDH1_STAAC]] Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells.<ref>PMID:18356528</ref>
[https://www.uniprot.org/uniprot/LDH1_STAAC LDH1_STAAC] Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells.<ref>PMID:18356528</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: L-lactate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staac]]
[[Category: Staphylococcus aureus subsp. aureus COL]]
[[Category: Almo, S C]]
[[Category: Almo SC]]
[[Category: Ho, M C]]
[[Category: Ho M-C]]
[[Category: Schramm, V L]]
[[Category: Schramm VL]]
[[Category: Alpha-beta motif]]
[[Category: Cytoplasm]]
[[Category: Glycolysis]]
[[Category: Nad]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]
[[Category: Rossmann fold]]
[[Category: Stress response]]

Latest revision as of 07:15, 6 September 2023

Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate

3h3j, resolution 1.80Å

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