3k6n: Difference between revisions

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<StructureSection load='3k6n' size='340' side='right'caption='[[3k6n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3k6n' size='340' side='right'caption='[[3k6n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6N FirstGlance]. <br>
<table><tr><td colspan='2'>[[3k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n9p|1n9p]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Girk1, Kcnj3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6n OCA], [https://pdbe.org/3k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6n RCSB], [https://www.ebi.ac.uk/pdbsum/3k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6n OCA], [https://pdbe.org/3k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6n RCSB], [https://www.ebi.ac.uk/pdbsum/3k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IRK3_MOUSE IRK3_MOUSE]] This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.  
[https://www.uniprot.org/uniprot/KCNJ3_MOUSE KCNJ3_MOUSE] This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Lu, Z]]
[[Category: Lu Z]]
[[Category: Shin, H G]]
[[Category: Shin HG]]
[[Category: Szep, S]]
[[Category: Szep S]]
[[Category: Xu, Y]]
[[Category: Xu Y]]
[[Category: Beta barrel]]
[[Category: Cytoplasmic domain]]
[[Category: G protein]]
[[Category: Inward rectifier]]
[[Category: Ion transport]]
[[Category: Ionic channel]]
[[Category: Metal transport]]
[[Category: Potassium channel]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/3k6n"