3kuv: Difference between revisions

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<StructureSection load='3kuv' size='340' side='right'caption='[[3kuv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3kuv' size='340' side='right'caption='[[3kuv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3kuv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptomyces_cattleya"_kahan_et_al._1979 "streptomyces cattleya" kahan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3kuv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kuw|3kuw]], [[3kv7|3kv7]], [[3kv8|3kv8]], [[3kvi|3kvi]], [[3kvu|3kvu]], [[3kvz|3kvz]], [[3kw1|3kw1]], [[3kx7|3kx7]], [[3kx8|3kx8]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">flK, fluoroacetyl-CoA thioesterase FlK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 "Streptomyces cattleya" Kahan et al. 1979])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuv OCA], [https://pdbe.org/3kuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuv RCSB], [https://www.ebi.ac.uk/pdbsum/3kuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuv OCA], [https://pdbe.org/3kuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuv RCSB], [https://www.ebi.ac.uk/pdbsum/3kuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT]] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref>
[https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuv_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces cattleya kahan et al. 1979]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blundell, T L]]
[[Category: Streptomyces cattleya]]
[[Category: Chirgadze, D Y]]
[[Category: Blundell TL]]
[[Category: Dias, M V.B]]
[[Category: Chirgadze DY]]
[[Category: Huang, F]]
[[Category: Dias MVB]]
[[Category: Leadlay, P F]]
[[Category: Huang F]]
[[Category: Spencer, J B]]
[[Category: Leadlay PF]]
[[Category: Spiteller, D]]
[[Category: Spencer JB]]
[[Category: Tosin, M]]
[[Category: Spiteller D]]
[[Category: Valentine, E F]]
[[Category: Tosin M]]
[[Category: Fluoroacetyl-coa thioesterase flk]]
[[Category: Valentine EF]]
[[Category: Hot dog folding]]
[[Category: Hydrolase]]
[[Category: Thioesterase]]
Retrieved from "https://proteopedia.org/3kuv"