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==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y7k|1y7k]], [[1hyk|1hyk]], [[1mr0|1mr0]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 21 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [https://pdbe.org/1y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [https://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [https://pdbe.org/1y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [https://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.  
[https://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7j_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7j_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barsh, G S]]
[[Category: Barsh GS]]
[[Category: Chai, B]]
[[Category: Chai B]]
[[Category: Dawson, P E]]
[[Category: Dawson PE]]
[[Category: Gantz, I]]
[[Category: Gantz I]]
[[Category: Jackson, P J]]
[[Category: Jackson PJ]]
[[Category: McNulty, J C]]
[[Category: McNulty JC]]
[[Category: Millhauser, G L]]
[[Category: Millhauser GL]]
[[Category: Thompson, D A]]
[[Category: Thompson DA]]
[[Category: Cystine knot]]
[[Category: Endogenous antagonist]]
[[Category: Gpcr]]
[[Category: Inhibitor]]
[[Category: Inverse agonist]]
[[Category: Melanocortin]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1y7j"