2ca7: Difference between revisions
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==Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization== | ==Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization== | ||
<StructureSection load='2ca7' size='340' side='right'caption='[[2ca7 | <StructureSection load='2ca7' size='340' side='right'caption='[[2ca7]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ca7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ca7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yl2 1yl2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca7 OCA], [https://pdbe.org/2ca7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca7 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca7 OCA], [https://pdbe.org/2ca7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/VKTS1_CONST VKTS1_CONST] Blocks specifically voltage-activated potassium channels (Kv) of the Shaker family (IC(50)=1.33 nM).<ref>PMID:15833744</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Conus striatus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bayrhuber | [[Category: Bayrhuber M]] | ||
[[Category: Becker | [[Category: Becker S]] | ||
[[Category: Ferber | [[Category: Ferber M]] | ||
[[Category: Garrett | [[Category: Garrett JE]] | ||
[[Category: Graf | [[Category: Graf R]] | ||
[[Category: Imperial | [[Category: Imperial J]] | ||
[[Category: Korukottu | [[Category: Korukottu J]] | ||
[[Category: Olivera | [[Category: Olivera BM]] | ||
[[Category: Terlau | [[Category: Terlau H]] | ||
[[Category: Vijayan | [[Category: Vijayan V]] | ||
[[Category: Zweckstetter | [[Category: Zweckstetter M]] | ||
