2vpj: Difference between revisions

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<StructureSection load='2vpj' size='340' side='right'caption='[[2vpj]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='2vpj' size='340' side='right'caption='[[2vpj]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vpj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vpj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpj OCA], [https://pdbe.org/2vpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpj RCSB], [https://www.ebi.ac.uk/pdbsum/2vpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpj OCA], [https://pdbe.org/2vpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpj RCSB], [https://www.ebi.ac.uk/pdbsum/2vpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KLH12_HUMAN KLH12_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).<ref>PMID:16547521</ref> <ref>PMID:18303015</ref> <ref>PMID:20100572</ref> <ref>PMID:22358839</ref> <ref>PMID:27565346</ref> <ref>PMID:27716508</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Bullock, A N]]
[[Category: Bullock AN]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Filippakopoulos P]]
[[Category: Filippakopoulos, P]]
[[Category: Keates T]]
[[Category: Keates, T]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Roos AK]]
[[Category: Roos, A K]]
[[Category: Salah E]]
[[Category: Salah, E]]
[[Category: Savitsky P]]
[[Category: Savitsky, P]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Von Delft F]]
[[Category: Adaptor protein]]
[[Category: Cul3]]
[[Category: Kelch repeat]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Protein-binding]]
[[Category: Ubiquitin degradation]]
[[Category: Ubl conjugation pathway]]
[[Category: Wnt signaling pathway]]
[[Category: Wnt signalling]]
Retrieved from "https://proteopedia.org/2vpj"