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==Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura==
==Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura==
<StructureSection load='1x22' size='340' side='right'caption='[[1x22]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1x22' size='340' side='right'caption='[[1x22]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1x22]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X22 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1x22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spodoptera_litura Spodoptera litura]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X22 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x22 OCA], [https://pdbe.org/1x22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x22 RCSB], [https://www.ebi.ac.uk/pdbsum/1x22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x22 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x22 OCA], [https://pdbe.org/1x22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x22 RCSB], [https://www.ebi.ac.uk/pdbsum/1x22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x22 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q7YZB4_SPOLT Q7YZB4_SPOLT]
An antibacterial peptide was isolated from a lepidopteran insect, Spodoptera litura. The molecular mass of this peptide was determined to be 4489.55 by matrix assisted laser desorption/ionization-time of flight mass (MALDI-TOF MS) spectrometry. The peptide consists of 42 amino acids and the sequence has 69-98% identity to those of moricin-related peptides, antibacterial peptides from lepidopetran insects. Thus, the peptide was designated S. litura (Sl) moricin. Sl moricin showed a broad antibacterial spectrum against Gram-positive and negative bacteria. Sl moricin gene was inducible by bacterial injection and expressed tissue-specifically in the fat body and hemocytes. Furthermore, the solution structure of Sl moricin was determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation. The tertiary structure revealed a long alpha-helix containing eight turns along nearly the full length of the peptide like that of moricin, confirming that Sl moricin is a new moricin-like antibacterial peptide. These results suggest that moricin is present not only in B. mori but also in other lepidopteran insects forming a gene family.
 
Isolation, gene expression and solution structure of a novel moricin analogue, antibacterial peptide from a lepidopteran insect, Spodoptera litura.,Oizumi Y, Hemmi H, Minami M, Asaoka A, Yamakawa M Biochim Biophys Acta. 2005 Aug 31;1752(1):83-92. PMID:16115804<ref>PMID:16115804</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1x22" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Asaoka, A]]
[[Category: Spodoptera litura]]
[[Category: Hemmi, H]]
[[Category: Asaoka A]]
[[Category: Minami, M]]
[[Category: Hemmi H]]
[[Category: Oizumi, Y]]
[[Category: Minami M]]
[[Category: Yamakawa, M]]
[[Category: Oizumi Y]]
[[Category: Antibacterial peptide]]
[[Category: Yamakawa M]]
[[Category: Antibiotic]]
[[Category: Gene expression]]
[[Category: Insect immunity]]
[[Category: Moricin]]
[[Category: Purification]]
[[Category: Solution structure]]
Retrieved from "https://proteopedia.org/1x22"