7q3f: Difference between revisions
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New page: '''Unreleased structure''' The entry 7q3f is ON HOLD Authors: Carrasco, K., Betzi, S., Morelli, X. Description: Bromodomain-containing 4 BD1 in complex with the inhibitor CRCM5484 [[Ca... |
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==Bromodomain-containing 4 BD1 in complex with the inhibitor CRCM5484== | |||
<StructureSection load='7q3f' size='340' side='right'caption='[[7q3f]], [[Resolution|resolution]] 1.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7q3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8M6:2-[[11-ethanoyl-4-(furan-2-ylmethyl)-3-oxidanylidene-8-thia-4,6,11-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-trien-5-yl]sulfanyl]-~{N}-(2-methylpyridin-3-yl)ethanamide'>8M6</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3f OCA], [https://pdbe.org/7q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3f RCSB], [https://www.ebi.ac.uk/pdbsum/7q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3f ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Betzi | </StructureSection> | ||
[[Category: Carrasco | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Betzi S]] | |||
[[Category: Carrasco K]] | |||
[[Category: Morelli X]] | |||
Latest revision as of 13:13, 1 February 2024
Bromodomain-containing 4 BD1 in complex with the inhibitor CRCM5484
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