Glucocorticoids: Difference between revisions
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<StructureSection load='3g6r' size='350' side='right' caption='Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry [[3g6r]])' scene=''> | <StructureSection load='3g6r' size='350' side='right' caption='Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry [[3g6r]])' scene=''> | ||
*[[Glucocorticoid receptor]] | Glucocorticoids are [[corticosteroids]] that bind to the glucocorticoid receptor. <scene name='89/895670/Cv/3'>Dexamethasone</scene> is a glucocorticoid medication. It is the most potent glucocorticoid and it has not mineralocorticoid potency. | ||
*[[Glucocorticoid receptor]]. | |||
**<scene name='89/895670/Cv/4'>Human glucocorticoid receptor ligand-binding domain bound to dexamethasone</scene> ([[1m2z]]). | |||
**<scene name='96/962959/Tert/1'>Glucocorticoid Receptor in complex with budesonide</scene> ([[5nfp]]). | |||
**<scene name='96/962959/Binding_site/1'>Budesonide binding site</scene>. Water molecule is shown as red sphere. | |||
**<scene name='97/973067/Binding_site/1'>Mometasone furoate binding site</scene>. | |||
*[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>. FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. | *[[Forkhead box proteins]] (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. '''FOXO1''' activation contributes to '''glucocorticoid'''-induced beta cell death<ref>PMID:23435785</ref>. FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. | ||
**<scene name='47/479231/Cv/5'>Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions</scene>. | **<scene name='47/479231/Cv/5'>Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions</scene>. | ||
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*Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>. Microsomal ''Prostaglandin E synthase'' <scene name='77/778890/Cv/2'>is membrane-associated</scene> (coordinates are from [http://opm.phar.umich.edu/protein.php?extrapdb=4yl0 OPM database]. The <scene name='77/778890/Cv/6'>anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix</scene><ref>PMID:25961169</ref>. Water molecules are shown as red spheres. | *Microsomal [[Prostaglandin E synthase]] (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2<ref>PMID:12432931</ref> . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory '''glucocorticoids'''<ref>PMID:16336776</ref>. Microsomal ''Prostaglandin E synthase'' <scene name='77/778890/Cv/2'>is membrane-associated</scene> (coordinates are from [http://opm.phar.umich.edu/protein.php?extrapdb=4yl0 OPM database]. The <scene name='77/778890/Cv/6'>anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix</scene><ref>PMID:25961169</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | |||
See also: | See also: | ||
*[[Nuclear | *[[Steroid Hormones and their receptors]] | ||
*[[Nuclear receptors]] | |||
*[[Corticosteroids]] | |||
*[[Budesonide]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
