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==Solution structure of the RNA binding domain of eukaryotic initiation factor 4B==
==Solution structure of the RNA binding domain of eukaryotic initiation factor 4B==
<StructureSection load='1wi8' size='340' side='right'caption='[[1wi8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wi8' size='340' side='right'caption='[[1wi8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA adSE02039 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi8 OCA], [https://pdbe.org/1wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi8 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi8 OCA], [https://pdbe.org/1wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi8 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IF4B_HUMAN IF4B_HUMAN]] Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.  
[https://www.uniprot.org/uniprot/IF4B_HUMAN IF4B_HUMAN] Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Muto, Y]]
[[Category: Muto Y]]
[[Category: Nagata, T]]
[[Category: Nagata T]]
[[Category: Structural genomic]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M]]
[[Category: Suzuki S]]
[[Category: Suzuki, S]]
[[Category: Terada T]]
[[Category: Terada, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Biosynthetic protein]]
[[Category: Rbd]]
[[Category: Rna binding domain]]
[[Category: Rna recognition motif]]
[[Category: Rnp]]
[[Category: Rrm]]
[[Category: Rsgi]]
Retrieved from "https://proteopedia.org/1wi8"