2zol: Difference between revisions

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<StructureSection load='2zol' size='340' side='right'caption='[[2zol]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2zol' size='340' side='right'caption='[[2zol]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zol]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zol]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_JHMV_/_variant_CL-2 Murine hepatitis virus strain JHMV / variant CL-2] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zok|2zok]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zol OCA], [https://pdbe.org/2zol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zol RCSB], [https://www.ebi.ac.uk/pdbsum/2zol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zol ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zol OCA], [https://pdbe.org/2zol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zol RCSB], [https://www.ebi.ac.uk/pdbsum/2zol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zol ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/SPIKE_CVMJC SPIKE_CVMJC]] S1 attaches the virion to the cell membrane by interacting with murine CEACAM1, initiating the infection (By similarity).  S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes (By similarity). [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Murine hepatitis virus strain JHMV / variant CL-2]]
[[Category: Dunstone, M A]]
[[Category: Mus musculus]]
[[Category: Rossjohn, J]]
[[Category: Dunstone MA]]
[[Category: Theodossis, A]]
[[Category: Rossjohn J]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Theodossis A]]
[[Category: Coiled coil]]
[[Category: Envelope protein]]
[[Category: Fusion protein]]
[[Category: Glycoprotein]]
[[Category: Host-virus interaction]]
[[Category: Ig fold]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Mhc i]]
[[Category: Polymorphism]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Virion]]
[[Category: Virulence]]
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