2ch0: Difference between revisions
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==Solution structure of the human MAN1 C-terminal domain (residues 655- 775)== | ==Solution structure of the human MAN1 C-terminal domain (residues 655- 775)== | ||
<StructureSection load='2ch0' size='340' side='right'caption='[[2ch0 | <StructureSection load='2ch0' size='340' side='right'caption='[[2ch0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ch0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ch0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch0 OCA], [https://pdbe.org/2ch0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch0 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch0 OCA], [https://pdbe.org/2ch0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN] Isolated osteopoikilosis;Buschke-Ollendorff syndrome;12q14 microdeletion syndrome;Melorheostosis with osteopoikilosis. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN] Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.<ref>PMID:15601644</ref> <ref>PMID:15647271</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Braud | [[Category: Braud S]] | ||
[[Category: Caputo | [[Category: Caputo S]] | ||
[[Category: Couprie | [[Category: Couprie J]] | ||
[[Category: Duband-Goulet | [[Category: Duband-Goulet I]] | ||
[[Category: Gilquin | [[Category: Gilquin B]] | ||
[[Category: Gondry | [[Category: Gondry M]] | ||
[[Category: Lin | [[Category: Lin F]] | ||
[[Category: Worman | [[Category: Worman HJ]] | ||
[[Category: Zinn-Justin | [[Category: Zinn-Justin S]] | ||
