Netrin: Difference between revisions

(5 intermediate revisions by the same user not shown)

Line 1:

== Function ==

'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.

'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>.

*'''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.

*'''Netrin-4''' promotes neurite elongation at low concentration and inhibits neurite elongation at high concentration<ref>PMID:19094984</ref>.

*'''Netrin-G1''' promotes the growth of dorsal thalamic axons.

*'''Netrin-G2''' plays a role in synaptic and pre-synaptic organisation<ref>PMID:31668703</ref>.

== Relevance ==

Line 25:

Line 29:

**[[6fkq]] – hNet1 V-VI domains + draxin peptide

**[[4ove]] – mNet1 – mouse

**[[4plm]] – cNet1 LN-LE3 domains – chicken

**[[9d77]] – cNet1 – chicken

**[[8tsm]] – cNet1 LN-LE2 domains 26-405

**[[4plm]], [[7ler]] – cNet1 LN-LE3 domains 26-457 – chicken

**[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains

**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains

**[[7lrf]] – cNet1 LN-LE3 domains + SOS

*Netrin-4

**[[4wnx]] – mNet4

**[[9az3]] – mNet4 43-326 + laminin subunit gamma – Cryo EM

*Netrin-G1

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 <StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'>
 == Function ==
-'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>.  '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.
+'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>.
+*'''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.
+*'''Netrin-4''' promotes neurite elongation at low concentration and inhibits neurite elongation at high concentration<ref>PMID:19094984</ref>.
+*'''Netrin-G1''' promotes the growth of dorsal thalamic axons.
+*'''Netrin-G2''' plays a role in synaptic and pre-synaptic organisation<ref>PMID:31668703</ref>.
 == Relevance ==
@@ Line 25: / Line 29: @@
 **[[6fkq]] – hNet1 V-VI domains + draxin peptide<BR />
 **[[4ove]] – mNet1 – mouse<BR />
-**[[4plm]] – cNet1 LN-LE3 domains – chicken<BR />
+**[[9d77]] – cNet1 – chicken<BR />
+**[[8tsm]] – cNet1 LN-LE2 domains 26-405 <BR />
+**[[4plm]], [[7ler]] – cNet1 LN-LE3 domains 26-457 – chicken<BR />
 **[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br />
 **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR />
+**[[7lrf]] – cNet1 LN-LE3 domains + SOS<br />
 *Netrin-4
 **[[4wnx]] – mNet4<BR />
+**[[9az3]] – mNet4 43-326 + laminin subunit gamma – Cryo EM<BR />
 *Netrin-G1