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New page: '''Unreleased structure''' The entry 7sqk is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 7sqk is ON HOLD
==Cryo-EM structure of the human augmin complex==
<StructureSection load='7sqk' size='340' side='right'caption='[[7sqk]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7sqk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqk OCA], [https://pdbe.org/7sqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqk RCSB], [https://www.ebi.ac.uk/pdbsum/7sqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HAUS1_HUMAN HAUS1_HUMAN] Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.<ref>PMID:15082789</ref> <ref>PMID:19369198</ref> <ref>PMID:19427217</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Accurate segregation of chromosomes during mitosis depends on the correct assembly of the mitotic spindle, a bipolar structure composed mainly of microtubules. The augmin complex, or homologous to augmin subunits (HAUS) complex, is an eight-subunit protein complex required for building robust mitotic spindles in metazoa. Augmin increases microtubule density within the spindle by recruiting the gamma-tubulin ring complex (gamma-TuRC) to pre-existing microtubules and nucleating branching microtubules. Here, we elucidate the molecular architecture of augmin by single particle cryo-electron microscopy (cryo-EM), computational methods, and crosslinking mass spectrometry (CLMS). Augmin's highly flexible structure contains a V-shaped head and a filamentous tail, with the head existing in either extended or contracted conformational states. Our work highlights how cryo-EM, complemented by computational advances and CLMS, can elucidate the structure of a challenging protein complex and provides insights into the function of augmin in mediating microtubule branching nucleation.


Authors:  
Molecular architecture of the augmin complex.,Gabel CA, Li Z, DeMarco AG, Zhang Z, Yang J, Hall MC, Barford D, Chang L Nat Commun. 2022 Sep 16;13(1):5449. doi: 10.1038/s41467-022-33227-7. PMID:36114186<ref>PMID:36114186</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 7sqk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chang L]]
[[Category: Gabel CA]]
Retrieved from "https://proteopedia.org/7sqk"