7ss1: Difference between revisions

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~~'''Unreleased structure'''~~

The ~~entry~~ 7ss1 is ~~ON HOLD~~

==The structure of NTMT1 in complex with compound GD433==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7ss1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SS1 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7SS1 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKF:(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl+{2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate'>AKF</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7ss1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ss1 OCA], [https://pdbe.org/7ss1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ss1 RCSB], [https://www.ebi.ac.uk/pdbsum/7ss1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ss1 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NTM1A_HUMAN NTM1A_HUMAN] Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.<ref>PMID:20481588</ref> <ref>PMID:20668449</ref> <ref>PMID:24090352</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Deng Y]]

[[Category: Guangping D]]

[[Category: Huang R]]

[[Category: Noinaj N]]

[[Category: Yadav R]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ss1 is ON HOLD
+==The structure of NTMT1 in complex with compound GD433==
+<StructureSection load='7ss1' size='340' side='right'caption='[[7ss1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ss1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SS1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKF:(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl+{2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate'>AKF</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ss1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ss1 OCA], [https://pdbe.org/7ss1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ss1 RCSB], [https://www.ebi.ac.uk/pdbsum/7ss1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ss1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NTM1A_HUMAN NTM1A_HUMAN] Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.<ref>PMID:20481588</ref> <ref>PMID:20668449</ref> <ref>PMID:24090352</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Deng Y]]
+[[Category: Guangping D]]
+[[Category: Huang R]]
+[[Category: Noinaj N]]
+[[Category: Yadav R]]